BrisEngBio funds four Discovery and eight Proof of Concept Projects to facilitate the translation of discovery synthetic biology research into new therapeutics, diagnostics and materials.
More details about these projects will be available soon.
Discovery
Designing peptides to intervene in subcellular processes
PIs: Mark Dodding, Dek Woolfson
Reprogramming wound inflammation with protocells
PIs: Paul Martin, Steve Mann
Ribosome engineering and CRISPR tools for optimising antimicrobial natural-product production
PI: Paul Curnow
3D printable memory matter in sustainable engineered living composites
PIs: Fabrizio Scarpa, Adam Perriman
Proof of Concept
Augmentable adhesive domains for glycan-targeted tissue-specific binding
PI: Fabio Parmeggiani
BioReplication for optical coatings and light intendance (BROCLI)
PIs: Rox Middleton and Heather Whitney
Design of photocatalytic nitrogenases
PI: Adrian Mulholland
Co-I: Adrian Bunzel
Whole-cell models
PI: Lucia Marucci
Co-I: Zahraa Abdallah, Claire Grierson, Paul Race
MEGAcryoFFAR: Megabody in vitro selection, evolution and engineering for cryo-EM structure analysis of FFAR1-bound lung fibrosis drugs to treat long COVID
PI: Christiane Berger-Schaffitzel
Co-I: Adrian Mulholland, Christopher Woods, Rich Pitts
Nanopore-based physiological monitoring of yeast for bioprocess optimisation
PI: Thomas Gorochowski
Co-I: Jeff Nivala
STING-SHIELD: Protein-delivery mediated innate immunity modulation to unlock maximal genome engineering and editing efficacy by SVNs in vivo
PI: Imre Berger
Co-I: Francesco Aulicino, Gavin Welsh, Moin Saleem
A versatile toolkit to functionalise magnetic nanoparticles for labelling and capture of bacteria
PI: Jim Spencer
Co-Is: Tomasso Garfagnini, Carmen Galan, Annela Seddon